| Year | Grand Prix | No. | Team | Maufacturer | Grid | Position | Pts Points |
|---|---|---|---|---|---|---|---|
| 2000 | Italian Grand Prix | 46 | Nastro Azzurro Honda | Honda | 3 | 12 | 4 |
| 2001 | Italian Grand Prix | 46 | Nastro Azzurro Honda | Honda | 1 | Ret | 0 |
| 2002 | Italian Grand Prix | 46 | Repsol Honda Team | Honda | 1 | 1 | 25 |
| 2003 | Italian Grand Prix | 46 | Repsol Honda | Honda | 1 | 1 | 25 |
| 2004 | Italian Grand Prix | 46 | Gauloises Fortuna Yamaha | Yamaha | 3 | 1 | 25 |
| 2005 | Italian Grand Prix | 46 | Gauloises Yamaha Team | Yamaha | 1 | 1 | 25 |
| 2006 | Italian Grand Prix | 46 | Camel Yamaha Team | Yamaha | 3 | 1 | 25 |
| 2007 | Italian Grand Prix | 46 | Fiat Yamaha Team | Yamaha | 3 | 1 | 25 |
| 2008 | Italian Grand Prix | 46 | Fiat Yamaha Team | Yamaha | 1 | 1 | 25 |
| 2009 | Italian Grand Prix | 46 | Fiat Yamaha Team | Yamaha | 4 | 3 | 16 |
| 2010 | Italian Grand Prix | 46 | Fiat Yamaha Team | Yamaha | DNS | 0 | |
| 2011 | Italian Grand Prix | 46 | Ducati Team | Ducati | 12 | 6 | 10 |
| 2012 | Italian Grand Prix | 46 | Ducati Team | Ducati | 10 | 5 | 11 |
| 2013 | Italian Grand Prix | 46 | Yamaha Factory Racing | Yamaha | 7 | Ret | 0 |
| 2014 | Italian Grand Prix | 46 | Movistar Yamaha MotoGP | Yamaha | 10 | 3 | 16 |
| 2015 | Italian Grand Prix | 46 | Movistar Yamaha MotoGP | Yamaha | 8 | 3 | 16 |
| 2016 | Italian Grand Prix | 46 | Movistar Yamaha MotoGP | Yamaha | 1 | Ret | 0 |
| 2017 | Italian Grand Prix | 46 | Movistar Yamaha MotoGP | Yamaha | 2 | 4 | 13 |
| 2018 | Italian Grand Prix | 46 | Movistar Yamaha MotoGP | Yamaha | 1 | 3 | 16 |
| 2019 | Italian Grand Prix | 46 | Monster Energy Yamaha MotoGP | Yamaha | 18 | Ret | 0 |
| 2021 | Italian Grand Prix | 46 | Petronas Yamaha SRT | Yamaha | 19 | 10 | 6 |
| Avg. | 5.5 | 3.5 | 17.7 |